Fatal case of donor-derived colistin-resistant carbapenemase-producing Klebsiella pneumoniae transmission in cardiac transplantation

Fatal case of donor-derived colistin-resistant carbapenemase-producing Klebsiella pneumoniae transmission in cardiac transplantation

Blog Article

Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation.A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation.On day 5 post-operation, blood cultures from the donor were positive for colistin-resistant carbapenemase-producing K.pneumoniae (ColR KPC-Kp) susceptible only to amikacin.Recipient blood cultures were also procharger ram 1500 5.7 positive for ColR KPC-Kp with the same sensitivity profile as the donor isolate with an identical PFGE pattern.

The patient was treated with double-carbapenems and amikacin.The patient evolved to pericarditis, osteomyelitis, and pulmonary necrosis, all fragment cultures positive for the same agent.The patient snoop snacks developed septic shock, multiple organ failure and died on day 50 post-transplantation.Based on current microbiological scenario worldwide the possibility of transmitting multidrug resistant (MDR) organisms should be considered.Keywords: Cardiac transplantation, Klebsiella pneumoniae, Donor-derived infection, Carbapenem-resistant.